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KMID : 0378019740170121687
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New Medical Journal
1974 Volume.17 No. 12 p.1687 ~ p.1695
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Urinary Excretion of Amylase in Dogs.
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Abstract
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It is generally accepted that in acute pancreatitis, the enzymes normally excreted by the pancreas from the disrupted parenchyma into the extraductal space and taken up by way of the lymphatics and capillaries.
The enzymes in the blood stream may appear in high concentration in the serum. Serum amylase determinations has long been a mainstay in the diagnosis of acute pancreatitis and other pancreatic diseases. However, many investigators have claimed that the urinary output of amylase may be elevated more consistently in acute pancreatitis than in the serum concentration of amylase, and urinary amylase measurement is a more sensitive reflector of the presence of pancreatitis and of its clinical course than the measurement of serum amylase.
The purpose of the present investigation was to observe the relationship between serum concentration and urinary output of amylase, resulting from the systemic administration of pancreatic enzymes.
These experimental procedures, consisted of heteroinfusion of human pancreatic juice and homoinfusion of canine pancreatic emulsion intravenously, and pancreatic ductal ligation in dogs.
Blood and urine samples for the enzyme analysis were collected serially through the femoral vein and ureteral catheter before and after the procedure. Activities of amylase was determined by methods of Nelson.
The results obtained are summarized as follows;
1. Following intravenous infusions of pancreatic juice exogenously, serum and urine concentrations of amylase increased rapidly, but this enzymes decreased rapidly in urinary excretion and gradually in serum concentration. Urinary recovery of amylase was approximately 10% of the total infused amount
of pancreatic juice at the end of 4 hours.
2. Following ligation of the pancreatic duct, the amylase levels of serum rose gradually and reached the maximum at 24-48 hours after ligation and then gradually fell. The output of this enzymes in the urine is relatively constant while serum enzymes were increased.
3. When the serum amylase level was increased by way of exogenous or endogenous, small proportion of amylase appeared in the urine. It suggested that increased amylase in the serum may be disappeared
by extraurinary mechanism.
4. Even though, several investigators have indicated that measurement of urinary amylase is more significant than serum amylase in the acute pancreatic diseases, however, the levels of amylase in the urine were less ´significant than serum amylase in these experiments.
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